Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 8/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20174121 | 0.89 | F2 (0.54) | F2PRSS1MAPK1CMA1 | |
| SCHEMBL20173779 | 0.84 | KMT2A (0.48) | ITGB3ITGA2BKMT2AF2PRSS1 | |
| SCHEMBL11661759 | 0.79 | KMT2A (0.64) | KMT2AALDH1A1LMNA | |
| SCHEMBL31186061 | 0.79 | KMT2A (0.64) | KMT2AALDH1A1LMNA | |
| SCHEMBL3046422 | 0.79 | KMT2A (0.64) | KMT2AALDH1A1LMNA | |
| SCHEMBL20174122 | 0.79 | OPRK1 (0.61) | F2 | |
| SCHEMBL23832913 | 0.78 | ACE (0.55) | KMT2AF2MAPK1CMA1ALDH1A1 | |
| SCHEMBL2262043 | 0.78 | ACE (0.55) | KMT2AF2MAPK1CMA1ALDH1A1 | |
| SCHEMBL10935144 | 0.78 | ACE (0.55) | KMT2AF2MAPK1CMA1ALDH1A1 | |
| SCHEMBL9510956 | 0.77 | KMT2A (0.52) | KMT2AF2PRSS1HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094335-A1 | FINE-TUNE MODULATORS OF NEURONAL EXCITABILITY FOR NEUROPSYCHIATRIC DISORDERS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2018-05-24 | — | — | WO | disclosed |