Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18359503 | 0.86 | PIK3CD (0.46) | ADORA3ADORA2AADORA2BADORA1PIK3CD | |
| SCHEMBL18359407 | 0.84 | PIK3CD (0.52) | ADORA3ADORA2AADORA2BADORA1PIK3CD | |
| SCHEMBL17933382 | 0.82 | ADORA3 (0.49) | ADORA3ADORA2AADORA2BADORA1PIK3CD | |
| SCHEMBL20163948 | 0.73 | HTR6 (0.33) | ADORA3ADORA2AADORA2BADORA1PDE4B | |
| SCHEMBL15720069 | 0.67 | PIK3CD (0.54) | ADORA3ADORA2AADORA2BADORA1PIK3CD | |
| SCHEMBL4754879 | 0.65 | HTR6 (0.40) | PDE4B | |
| SCHEMBL11357015 | 0.64 | SMN1; SMN2 (0.47) | — | |
| SCHEMBL7881518 | 0.64 | ADORA3 (0.48) | GRM5ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL22438726 | 0.63 | DCTPP1 (0.54) | — | |
| SCHEMBL4068273 | 0.63 | ADORA3 (0.71) | ADORA3ADORA2AADORA2BADORA1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180141947-A1 | Purine Inhibitors of Human Phosphatidylinositol 3-Kinase Delta | MERCK SHARP & DOHME CORP. (US) | 2018-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180141947-A1 | Purine Inhibitors of Human Phosphatidylinositol 3-Kinase Delta | PIK3CD, PIK3CA, PI4KA | GRM5 3104/4885ADORA3 29/4885ADORA2A 84/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.