SCHEMBL20177637

SCHEMBL20177637

COc1ccc(COC(=O)N[C@@H]2C(=S)NC[C@H]2c2ccc(Br)cc2)cc1

nearest known ligand 0.44

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
FPR1 P21462 7/20 0.44
ALDH1A1 P00352 2/20 0.43
KMT2A Q03164 1/20 0.43
PKM P14618 1/20 0.42
HTT P42858 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
NAAA Q02083 7/20 0.41
ASAH1 Q13510 2/20 0.41
FPR2 P25090 5/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20177949 0.90 FPR1 (0.52) FPR1PKMHTTSMN1; SMN2NAAA
SCHEMBL20177842 0.89 FPR1 (0.53) FPR1NAAAASAH1FPR2
SCHEMBL20177565 0.87 FPR1 (0.43) FPR1ALDH1A1KMT2APKMHTT
SCHEMBL20177669 0.85 FPR1 (0.43) FPR1ALDH1A1KMT2APKMHTT
SCHEMBL20177604 0.85 FPR2 (0.47) FPR1ALDH1A1PKMHTTSMN1; SMN2
SCHEMBL20177552 0.81 EDNRB (0.40) ALDH1A1KMT2APKMHTTSMN1; SMN2
SCHEMBL20177658 0.80 FPR2 (0.48) FPR1ALDH1A1PKMHTTSMN1; SMN2
SCHEMBL20177501 0.79 FPR2 (0.47) FPR1PKMHTTSMN1; SMN2NAAA
SCHEMBL20177511 0.79 FPR2 (0.67) FPR1NAAAASAH1FPR2
SCHEMBL18578943 0.78 FPR1 (0.55) FPR1NAAAASAH1FPR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018092916-A1 NITROGEN-CONTAINING POLYCYCLIC HETEROCYCLIC DERIVATIVE 宇部興産株式会社 2018-05-24 WO disclosed