SCHEMBL20177931

SCHEMBL20177931

COC(CNC1=NC[C@@H](c2c(F)cc(Br)cc2F)[C@@H]1NC(=O)OCc1ccccc1)OC

nearest known ligand 0.39

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KCNQ2 O43526 1/20 0.39
KDM1A O60341 2/20 0.38
FPR2 P25090 1/20 0.37
NAAA Q02083 2/20 0.36
CPB1 P15086 1/20 0.35
ALDH1A1 P00352 1/20 0.35
GAA P10253 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
ACHE P22303 1/20 0.35
TSHR P16473 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20177608 0.92 FPR2 (0.46) KCNQ2FPR2NAAACPB1CA1
SCHEMBL16785452 0.79 FPR2 (0.49) KCNQ2FPR2CPB1ALDH1A1GAA
SCHEMBL16785365 0.77 FPR2 (0.50) KCNQ2FPR2CA1CA2ACHE
SCHEMBL18264314 0.76 FPR2 (0.50) FPR2
SCHEMBL18264312 0.76 FPR2 (0.50) FPR2
SCHEMBL20177587 0.75 CA1 (0.47) KCNQ2FPR2CPB1ALDH1A1GAA
SCHEMBL20177567 0.74 FPR2 (0.52) FPR2NAAA
SCHEMBL20177919 0.74 KDM1A (0.41) KDM1AFPR2NAAAALDH1A1GAA
SCHEMBL20528327 0.73 FPR2 (0.44) KCNQ2FPR2CA1CA2ACHE
SCHEMBL20177674 0.72 KDM1A (0.42) KDM1AFPR2NAAACPB1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018092916-A1 NITROGEN-CONTAINING POLYCYCLIC HETEROCYCLIC DERIVATIVE 宇部興産株式会社 2018-05-24 WO disclosed