Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | F9 | P00740 | 1/20 | 0.32 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.31 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.31 |
| ▸ | YAP1 | P46937 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20179173 | 0.86 | SLC7A5 (0.44) | LTA4HCTSBCTSSCTSKSLC7A5 | |
| SCHEMBL21570571 | 0.86 | LMNA (0.46) | LTA4HCTSBCTSSCTSKSLC7A5 | |
| SCHEMBL20168691 | 0.83 | FOLH1 (0.47) | LTA4HSLC7A5FOLH1LMNAGAA | |
| SCHEMBL20179186 | 0.83 | SLC7A5 (0.49) | LTA4HSLC7A5FOLH1KMT2ALMNA | |
| SCHEMBL20168291 | 0.78 | FOLH1 (0.50) | LTA4HFOLH1POLBLMNA | |
| SCHEMBL20179243 | 0.78 | FOLH1 (0.42) | LTA4HSLC7A5FOLH1POLBLMNA | |
| SCHEMBL21577931 | 0.78 | SLC7A5 (0.45) | LTA4HCTSBCTSSCTSKSLC7A5 | |
| SCHEMBL21577906 | 0.77 | LMNA (0.50) | FOLH1HPGDLMNAGAA | |
| SCHEMBL20179218 | 0.77 | LMNA (0.50) | FOLH1HPGDLMNAGAA | |
| SCHEMBL20179268 | 0.77 | LMNA (0.50) | FOLH1HPGDLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094334-A1 | PRODRUGS OF HYDROXAMATE-BASED GCPII INHIBITORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2018-05-24 | — | — | WO | disclosed |