SCHEMBL20180153

SCHEMBL20180153

N=C(c1ccccc1)c1c(Nc2cccc(Br)c2)ccc2ccc(-c3ccncc3)cc12

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALK Q9UM73 1/20 0.41
ABCG2 Q9UNQ0 8/20 0.40
ABCB1 P08183 4/20 0.40
PKMYT1 Q99640 1/20 0.40
EGFR P00533 1/20 0.40
PTGS1 P23219 2/20 0.39
PTGS2 P35354 2/20 0.39
ABCC1 P33527 2/20 0.38
LMNA P02545 2/20 0.36
HPGD P15428 2/20 0.36
HDAC2 Q92769 2/20 0.36
HDAC3 O15379 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
ALDH1A1 P00352 1/20 0.36
POLB P06746 1/20 0.36
GSK3A P49840 1/20 0.36
GSK3B P49841 1/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20615283 0.79 ADRA2A (0.42) EGFRPTGS1PTGS2LMNAHPGD
SCHEMBL20615581 0.76 CDC25B (0.45) ALKABCG2ABCB1EGFRLMNA
SCHEMBL20180123 0.73 EGFR (0.45) ABCG2EGFRPTGS1PTGS2LMNA
SCHEMBL20180161 0.72 PTGS1 (0.43) ALKPKMYT1EGFRPTGS1PTGS2
SCHEMBL22214810 0.72 TGFBR1 (0.44) ABCG2ABCB1LMNAHPGDALDH1A1
SCHEMBL22214776 0.71 SIRT2 (0.40) ABCG2ABCB1LMNAHPGDALDH1A1
SCHEMBL20180548 0.70 MEN1 (0.43) ABCG2ABCB1ABCC1LMNAHPGD
SCHEMBL20180146 0.69 ABCG2 (0.38) ALKABCG2ABCB1EGFRABCC1
SCHEMBL4357891 0.68 EGFR (0.58) ABCG2ABCB1EGFR
SCHEMBL22214790 0.68 TP53 (0.41) ABCG2ABCB1LMNAHPGDALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018093107-A1 ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT ELEMENT COMPRISING SAME 주식회사 두산 2018-05-24 WO disclosed