SCHEMBL20180183

SCHEMBL20180183

c1ccc(-c2nc(-c3ccccc3)nc(-c3cccc(-c4cccc(-c5cccc(-n6ncc7c8ccccc8ccc76)c5)c4)c3)n2)cc1

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.40
RAB9A P51151 3/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
NR3C1 P04150 2/20 0.40
LMNA P02545 1/20 0.40
MAPT P10636 1/20 0.40
RECQL P46063 1/20 0.40
KHK P50053 1/20 0.38
PIK3CA P42336 3/20 0.37
MTOR P42345 3/20 0.37
IRAK4 Q9NWZ3 1/20 0.37
ALDH1A1 P00352 1/20 0.36
POLB P06746 1/20 0.36
CYP17A1 P05093 1/20 0.35
CYP1A2 P05177 1/20 0.35
GP6 Q9HCN6 1/20 0.35
ATM Q13315 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20180181 0.91 NR3C1 (0.44) NR3C1KHKPIK3CAMTORIRAK4
SCHEMBL18915545 0.84 CDK4 (0.34) NR3C1KHKPIK3CAMTORIRAK4
SCHEMBL18915505 0.83 PIK3CA (0.35) NPC1RAB9ASMN1; SMN2NR3C1LMNA
SCHEMBL20180304 0.83 NR3C1 (0.47) NPC1RAB9ANR3C1KHKIRAK4
SCHEMBL20180230 0.82 NR3C1 (0.59) NR3C1KHKIRAK4
SCHEMBL18914970 0.81 PIK3CA (0.36) NPC1RAB9ASMN1; SMN2NR3C1LMNA
SCHEMBL20180350 0.81 NR3C1 (0.45) NPC1RAB9ANR3C1KHKIRAK4
SCHEMBL20180412 0.81 NR3C1 (0.61) NR3C1KHKIRAK4
SCHEMBL18915495 0.81 PIK3CA (0.34) NPC1RAB9ASMN1; SMN2NR3C1LMNA
SCHEMBL20180272 0.81 ALOX5 (0.37) NPC1RAB9AMAPTPIK3CAMTOR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018093107-A1 ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT ELEMENT COMPRISING SAME 주식회사 두산 2018-05-24 WO disclosed