SCHEMBL20180533

SCHEMBL20180533

N=C(C1=CCCC=C1)c1ccccc1Nc1cccc(Br)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
SIRT2 Q8IXJ6 4/20 0.38
EGFR P00533 3/20 0.37
P2RX1 P51575 1/20 0.36
SIRT1 Q96EB6 3/20 0.35
TAS2R14 Q9NYV8 2/20 0.34
ABCG2 Q9UNQ0 1/20 0.34
AURKA O14965 1/20 0.34
RPS6KB1 P23443 1/20 0.34
KDM4E B2RXH2 1/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
PTGS1 P23219 1/20 0.34
PTGS2 P35354 1/20 0.34
AKR1C3 P42330 1/20 0.34
AKR1C2 P52895 1/20 0.34
HTT P42858 1/20 0.34
MPO P05164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20180393 0.87 SIRT2 (0.39) ALDH1A1NPC1RAB9ASIRT2EGFR
SCHEMBL17454730 0.79 MAPT (0.43) ALDH1A1SIRT2KDM4EMEN1KMT2A
SCHEMBL23783789 0.74 KDM4E (0.40) ALDH1A1KDM4E
SCHEMBL20180123 0.73 EGFR (0.45) ALDH1A1NPC1RAB9ASIRT2EGFR
SCHEMBL20615335 0.72 MEN1 (0.48) ALDH1A1NPC1RAB9ASIRT2SIRT1
SCHEMBL384593 0.70 FABP4 (0.65) ALDH1A1NPC1RAB9ASIRT2P2RX1
SCHEMBL14137199 0.70 EGFR (0.57) ALDH1A1EGFRABCG2KDM4EMEN1
SCHEMBL338231 0.67 P2RX1 (0.62) ALDH1A1NPC1RAB9ASIRT2P2RX1
SCHEMBL28660772 0.67 MAPT (0.69) ALDH1A1NPC1RAB9ASIRT2P2RX1
SCHEMBL14339391 0.67 EGFR (0.54) ALDH1A1EGFRABCG2KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018093107-A1 ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT ELEMENT COMPRISING SAME 주식회사 두산 2018-05-24 WO disclosed