Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 8/20 | 0.57 |
| ▸ | DRD1 | P21728 | 3/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20180267 | 0.76 | DGAT2 (0.51) | DGAT2TP53 | |
| SCHEMBL20166221 | 0.73 | DGAT2 (1.00) | DGAT2 | |
| SCHEMBL12334437 | 0.67 | POLB (0.49) | PPARGMAPTKDM4ETP53HTT | |
| SCHEMBL13051741 | 0.66 | HTT (0.46) | PPARGMAPTKDM4EHTT | |
| SCHEMBL856123 | 0.66 | DRD1 (0.68) | DRD1MAOAMAOBMAPT | |
| SCHEMBL29391855 | 0.66 | DRD1 (0.68) | DRD1MAOAMAOBMAPT | |
| SCHEMBL13299344 | 0.63 | IP6K1 (0.43) | KDM4E | |
| SCHEMBL11986618 | 0.63 | NR3C1 (0.40) | DGAT2KDM4E | |
| SCHEMBL20526641 | 0.62 | JAK2 (0.48) | KDM4EHTT | |
| SCHEMBL12489894 | 0.62 | POLB (0.51) | PPARGMAPTKDM4ETP53HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018093698-A1 | INDOLE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | MERCK SHARP & DOHME CORP. (US) | 2018-05-24 | — | — | WO | disclosed |