Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | APLNR | P35414 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13083762 | 0.86 | GABRA1 (0.41) | LMNAHTTKDM4EALDH1A1MAPT | |
| SCHEMBL2015924 | 0.84 | KDM4E (0.39) | LMNATP53HTTKDM4EALDH1A1 | |
| SCHEMBL8204161 | 0.82 | LMNA (0.42) | LMNATP53HTTPDE2AALDH1A1 | |
| SCHEMBL31683735 | 0.80 | LMNA (0.41) | LMNATP53HTTPDE2AALDH1A1 | |
| SCHEMBL31683734 | 0.80 | LMNA (0.41) | LMNATP53HTTPDE2AALDH1A1 | |
| SCHEMBL8164587 | 0.80 | LMNA (0.41) | LMNATP53HTTPDE2AALDH1A1 | |
| SCHEMBL121332 | 0.80 | LMNA (0.41) | LMNATP53HTTPDE2AALDH1A1 | |
| SCHEMBL16793738 | 0.80 | LMNA (0.41) | LMNATP53HTTPDE2AALDH1A1 | |
| SCHEMBL2100743 | 0.80 | GABRA1 (0.45) | LMNATP53HTTPDE2AHTR2A | |
| SCHEMBL22303989 | 0.79 | ALDH1A1 (0.41) | KDM4EALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |