Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL283021 | 0.84 | GABRA1 (0.46) | KDM4EGLAGAAHTTMAPT | |
| SCHEMBL2018114 | 0.84 | LMNA (0.42) | KDM4EGLAHTTLMNATP53 | |
| SCHEMBL3984863 | 0.81 | KDM4E (0.42) | KDM4EGLAGAAHTTMAPT | |
| SCHEMBL2100743 | 0.78 | GABRA1 (0.45) | HTTLMNATP53GABRA1GABRB1 | |
| SCHEMBL249883 | 0.78 | HPGD (0.41) | KDM4EGLAGAAMAPTALDH1A1 | |
| SCHEMBL6486185 | 0.77 | CASP1 (0.41) | GLAGAAHTTLMNATP53 | |
| SCHEMBL20238210 | 0.77 | PDE2A (0.43) | HTTLMNATP53GABRA1GABRB1 | |
| SCHEMBL20855720 | 0.77 | ALOX15 (0.46) | KDM4EGAAHTTLMNATP53 | |
| SCHEMBL20855723 | 0.77 | ALOX15 (0.46) | KDM4EGAAHTTLMNATP53 | |
| SCHEMBL14987514 | 0.77 | PDE2A (0.43) | HTTLMNATP53GABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903978-B1 | GDF-8 INHIBITORS | RIGEL PHARMACEUTICALS INC (US) | 2022-12-07 | — | — | EP | disclosed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |