Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 6/20 | 0.39 |
| ▸ | EYA3 | Q99504 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20181565 | 0.87 | SLC22A12 (0.43) | SLC22A12NPC1RAB9AHTTLMNA | |
| SCHEMBL18629834 | 0.84 | MAPK1 (0.50) | NPC1HPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL20181666 | 0.82 | MAPT (0.43) | RAB9AHTTESR1ESR2LMNA | |
| SCHEMBL22623471 | 0.81 | MAPK1 (0.36) | SLC22A12EYA3NPC1RAB9AHTT | |
| SCHEMBL18629887 | 0.79 | HTT (0.37) | SLC22A12EYA3NPC1RAB9AHTT | |
| SCHEMBL22623466 | 0.79 | ESR1 (0.36) | SLC22A12EYA3HTTESR1ESR2 | |
| SCHEMBL20181564 | 0.79 | LMNA (0.43) | NPC1RAB9AHTTLMNAMAPT | |
| SCHEMBL21191865 | 0.78 | HDAC1 (0.33) | SLC22A12EYA3NPC1RAB9AHTT | |
| SCHEMBL20181584 | 0.76 | MAPK1 (0.48) | NPC1RAB9AHTTESR1ESR2 | |
| SCHEMBL20181614 | 0.74 | ALDH1A1 (0.50) | SLC22A12EYA3RAB9AHTTESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE50083-E1 | URAT1 inhibitor and use thereof | JIANGSU ATOM BIOSCIENCE AND PHARMACEUTICAL CO., LTD. (CN) | 2024-08-20 | — | — | US | disclosed |
| US-11597725-B2 | URAT1 inhibitor for promoting uric acid excretion | JIANGSU ATOM BIOSCIENCE AND PHARMACEUTICAL CO., LTD. (CN) | 2023-03-07 | — | — | US | disclosed |
| EP-3543240-B1 | URAT1 INHIBITOR AND USE THEREOF | JIANGSU ATOM BIOSCIENCE AND PHARMACEUTICAL CO LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3543240-B1 | URAT1 INHIBITOR AND USE THEREOF | JIANGSU ATOM BIOSCIENCE AND PHARMACEUTICAL CO LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3632904-B1 | URAT1 INHIBITORS FOR PROMOTING URIC ACID EXCRETION | JIANGSU ATOM BIOSCIENCE AND PHARMACEUTICAL CO LTD (CN) | 2022-04-20 | — | — | EP | disclosed |
| EP-3632904-B1 | URAT1 INHIBITORS FOR PROMOTING URIC ACID EXCRETION | JIANGSU ATOM BIOSCIENCE AND PHARMACEUTICAL CO LTD (CN) | 2022-04-20 | — | — | EP | disclosed |
| US-10875865-B2 | URAT1 inhibitor and use thereof | JIANGSU ATOM BIOSCIENCE AND PHARMACEUTICAL CO., LTD. (CN) | 2020-12-29 | — | — | US | disclosed |
| US-10875865-B2 | URAT1 inhibitor and use thereof | JIANGSU ATOM BIOSCIENCE AND PHARMACEUTICAL CO., LTD. (CN) | 2020-12-29 | — | — | US | disclosed |
| US-20200262832-A1 | URAT1 INHIBITOR FOR PROMOTING URIC ACID EXCRETION | JIANGSU ATOM BIOSCIENCE AND PHARMACEUTICAL CO., LTD. (CN) | 2020-08-20 | — | — | US | disclosed |
| EP-3632904-A1 | URAT1 INHIBITOR FOR PROMOTING URIC ACID EXCRETION | Jiangsu Atom Bioscience And Pharmaceutical Co., Ltd. (CN) | 2020-04-08 | — | — | EP | disclosed |
| US-20200062763-A1 | URAT1 INHIBITOR AND USE THEREOF | JIANGSU ATOM BIOSCIENCE AND PHARMACEUTICAL CO., LTD. (CN) | 2020-02-27 | — | — | US | disclosed |
| US-20200062763-A1 | URAT1 INHIBITOR AND USE THEREOF | JIANGSU ATOM BIOSCIENCE AND PHARMACEUTICAL CO., LTD. (CN) | 2020-02-27 | — | — | US | disclosed |
| EP-3543240-A1 | URAT1 INHIBITOR AND USE THEREOF | Jiangsu Atom Bioscience And Pharmaceutical Co., Ltd. (CN) | 2019-09-25 | — | — | EP | disclosed |
| WO-2018090921-A1 | URAT1 INHIBITOR AND USE THEREOF | 江苏新元素医药科技有限公司 | 2018-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11597725-B2 | URAT1 inhibitor for promoting uric acid excretion | SLC10A6, SLC10A1, SLC28A1 | SLC22A12 35/4885EYA3 2625/4885NPC1 163/4885 |
| US-20200062763-A1 | URAT1 INHIBITOR AND USE THEREOF | SLC14A1, SLC10A6, SLC10A1 | SLC22A12 39/4885EYA3 2921/4885NPC1 150/4885 |
| US-10875865-B2 | URAT1 inhibitor and use thereof | SLC14A1, SLC10A6, SLC10A1 | SLC22A12 39/4885EYA3 2921/4885NPC1 150/4885 |
| US-20200262832-A1 | URAT1 INHIBITOR FOR PROMOTING URIC ACID EXCRETION | SLC10A6, SLC10A1, SLC28A1 | SLC22A12 35/4885EYA3 2625/4885NPC1 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.