Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | BTN3A1 | O00481 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 7/20 | 0.34 |
| ▸ | METAP1 | P53582 | 6/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | FBP1 | P09467 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25766390 | 0.86 | TP53 (0.36) | TDP1TP53BTN3A1GAACYP3A4 | |
| SCHEMBL28855412 | 0.86 | ALDH1A1 (0.41) | TDP1BTN3A1GAACYP3A4ALDH1A1 | |
| SCHEMBL20168386 | 0.84 | ALDH1A1 (0.42) | TDP1TP53GAACYP3A4ALDH1A1 | |
| SCHEMBL20168384 | 0.84 | ALDH1A1 (0.42) | TDP1TP53GAACYP3A4ALDH1A1 | |
| SCHEMBL20181801 | 0.80 | BTN3A1 (0.37) | BTN3A1GAAALDH1A1TSHRMGAM | |
| SCHEMBL22356079 | 0.79 | METAP2 (0.37) | BTN3A1GAACYP3A4ALDH1A1ALOX15 | |
| SCHEMBL21704812 | 0.79 | BTN3A1 (0.36) | BTN3A1GAAMGAMSIMGAM2 | |
| SCHEMBL19235724 | 0.77 | BTN3A1 (0.36) | TDP1BTN3A1GAACYP3A4ALDH1A1 | |
| SCHEMBL20181544 | 0.77 | MGAM (0.39) | BTN3A1GAAALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL13633863 | 0.77 | MGAM (0.39) | TDP1BTN3A1GAACYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11279694-B2 | Alvocidib prodrugs and their use as protein kinase inhibitors | SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC. (US) | 2022-03-22 | — | — | US | disclosed |
| US-20200048228-A1 | ALVOCIDIB PRODRUGS AND THEIR USE AS PROTEIN KINASE INHIBITORS | SUMITOMO PHARMA ONCOLOGY, INC. | 2020-02-13 | — | — | US | disclosed |
| WO-2018094275-A1 | ALVOCIDIB PRODRUGS AND THEIR USE AS PROTEIN KINASE INHIBITORS | TOLERO PHARMACEUTICALS, INC. (US) | 2018-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11279694-B2 | Alvocidib prodrugs and their use as protein kinase inhibitors | CDK1, CDK2, CDK3 | TDP1 470/4885TP53 447/4885BTN3A1 4189/4885 |
| US-20200048228-A1 | ALVOCIDIB PRODRUGS AND THEIR USE AS PROTEIN KINASE INHIBITORS | CDK1, CDK2, CDK3 | TDP1 470/4885TP53 447/4885BTN3A1 4189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.