Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 8/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.35 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TEC | P42680 | 1/20 | 0.32 |
| ▸ | TXK | P42681 | 1/20 | 0.32 |
| ▸ | BMX | P51813 | 1/20 | 0.32 |
| ▸ | ITK | Q08881 | 1/20 | 0.32 |
| ▸ | HTR5A | P47898 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2016578 | 0.93 | CNR2 (0.38) | BTKAKT1L3MBTL1NPC1ALOX12 | |
| SCHEMBL2014688 | 0.92 | NPC1 (0.37) | BTKMTNR1AMTNR1BL3MBTL1TEC | |
| SCHEMBL2014572 | 0.87 | AKT1 (0.38) | AKT1CNR2 | |
| SCHEMBL2018204 | 0.86 | PIK3CD (0.41) | BTKMTNR1AMTNR1BHMOX1PIK3CD | |
| SCHEMBL2014980 | 0.86 | SLC40A1 (0.38) | PIK3CDL3MBTL1HTR5ANPC1ALOX12 | |
| SCHEMBL2014977 | 0.86 | SLC40A1 (0.38) | PIK3CDL3MBTL1HTR5ANPC1ALOX12 | |
| SCHEMBL2017050 | 0.85 | SLC40A1 (0.40) | PIK3CDL3MBTL1HTR5ANPC1ALOX12 | |
| SCHEMBL2017715 | 0.84 | MTNR1A (0.41) | MTNR1AMTNR1BHMOX1L3MBTL1HTR5A | |
| Trifluoroacetic Acid SCHEMBL2013515 | 0.83 | SLC40A1 (0.36) | L3MBTL1RAB9A | |
| SCHEMBL2015211 | 0.82 | AXL (0.32) | PIK3CDL3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | claimed |
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |