Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | USP5 | P45974 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12628187 | 1.00 | ALDH1A1 (0.53) | ALDH1A1RAB9AKMT2AGAAEPHX2 | |
| SCHEMBL2016436 | 0.87 | ALDH1A1 (0.52) | ALDH1A1RAB9AKMT2AGAAEPHX2 | |
| SCHEMBL12628299 | 0.87 | ALDH1A1 (0.52) | ALDH1A1RAB9AKMT2AGAAEPHX2 | |
| SCHEMBL2016241 | 0.87 | ALDH1A1 (0.52) | ALDH1A1RAB9AKMT2AGAAEPHX2 | |
| SCHEMBL12628522 | 0.86 | ALDH1A1 (0.51) | ALDH1A1RAB9AKMT2AGAAEPHX2 | |
| SCHEMBL2016541 | 0.85 | ALDH1A1 (0.52) | ALDH1A1RAB9AKMT2AGAAEPHX2 | |
| SCHEMBL2013487 | 0.84 | ALDH1A1 (0.49) | ALDH1A1RAB9AKMT2AGAAEPHX2 | |
| SCHEMBL12628295 | 0.84 | ALDH1A1 (0.49) | ALDH1A1RAB9AKMT2AGAAEPHX2 | |
| SCHEMBL2011559 | 0.84 | ALDH1A1 (0.49) | ALDH1A1RAB9AKMT2AGAAEPHX2 | |
| SCHEMBL12629087 | 0.82 | ALDH1A1 (0.65) | ALDH1A1RAB9AKMT2ALMNAPSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073269-A1 | PIPERIDINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | claimed |