Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 5/20 | 0.36 |
| ▸ | LCK | P06239 | 2/20 | 0.36 |
| ▸ | TEK | Q02763 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | EIF2AK3 | Q9NZJ5 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | ADK | P55263 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CFD | P00746 | 2/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | PI4KA | P42356 | 1/20 | 0.31 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.31 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.31 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20182236 | 0.78 | KDR (0.36) | LRRK2SRCLCKTEKKDR | |
| SCHEMBL20182248 | 0.73 | LRRK2 (0.34) | LRRK2SRCLCKTEKKDR | |
| SCHEMBL20279326 | 0.70 | RIPK1 (0.32) | — | |
| SCHEMBL20181911 | 0.69 | EIF2AK3 (0.37) | SRCLCKTEKEIF2AK3 | |
| SCHEMBL20173329 | 0.69 | EIF2AK3 (0.38) | SRCLCKTEKEIF2AK3 | |
| SCHEMBL17406879 | 0.69 | KDM4E (0.59) | SRCLCKTEKEGFRCDK1 | |
| SCHEMBL20182264 | 0.68 | SRC (0.35) | LRRK2SRCLCKTEKEIF2AK3 | |
| SCHEMBL23283623 | 0.68 | PSIP1 (0.40) | KDM4E | |
| SCHEMBL20182196 | 0.68 | EIF2AK3 (0.37) | SRCLCKTEKEIF2AK3FLT3 | |
| SCHEMBL23885181 | 0.67 | ADK (0.43) | SRCLCKTEKKDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094137-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. (US) | 2018-05-24 | — | — | WO | disclosed |