Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13178692 | 0.77 | NOS1 (0.41) | — | |
| SCHEMBL24387256 | 0.73 | TRPM5 (0.45) | TRPM5 | |
| SCHEMBL24387253 | 0.72 | — | — | |
| SCHEMBL20093614 | 0.67 | L3MBTL1 (0.38) | — | |
| SCHEMBL19400985 | 0.66 | PSEN1 (0.32) | — | |
| SCHEMBL19003615 | 0.65 | HCAR2 (0.46) | — | |
| SCHEMBL2669058 | 0.62 | — | — | |
| SCHEMBL16104019 | 0.62 | — | — | |
| SCHEMBL20794217 | 0.62 | PSEN1 (0.34) | — | |
| SCHEMBL24567919 | 0.61 | FPR3 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018093694-A1 | DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | MERCK SHARP & DOHME CORP. (US) | 2018-05-24 | — | — | WO | disclosed |