Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ACSS2 | Q9NR19 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2018097 | 0.88 | HTT (0.59) | HTTMEN1KMT2AHDAC6SMN1; SMN2 | |
| SCHEMBL20191187 | 0.86 | HTT (0.51) | HTTRPS6KA5MEN1KMT2AHDAC6 | |
| SCHEMBL20204947 | 0.84 | MTNR1A (0.55) | HTTACSS2MAPT | |
| SCHEMBL12636253 | 0.83 | ACSS2 (0.47) | HTTRPS6KA5SMN1; SMN2ACSS2LMNA | |
| SCHEMBL4036510 | 0.83 | S1PR1 (0.52) | HTTACSS2 | |
| SCHEMBL2014823 | 0.78 | HTT (0.45) | HTTRPS6KA5MEN1KMT2ATP53 | |
| SCHEMBL17066160 | 0.78 | RPS6KA5 (0.45) | HTTRPS6KA5MEN1KMT2AHDAC6 | |
| SCHEMBL12636271 | 0.76 | HTT (0.39) | HTTRPS6KA5MEN1KMT2AHDAC6 | |
| SCHEMBL2041269 | 0.75 | GAA (0.44) | RPS6KA5HDAC6ACSS2MAPT | |
| SCHEMBL16408252 | 0.73 | RPS6KA5 (0.43) | HTTRPS6KA5SMN1; SMN2ACSS2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |