Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | ACSS2 | Q9NR19 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2018295 | 0.88 | HTT (0.52) | HTTACSS2MAPTMEN1KMT2A | |
| SCHEMBL20191187 | 0.87 | HTT (0.51) | HTTACSS2MEN1KMT2AHDAC6 | |
| SCHEMBL20204947 | 0.85 | MTNR1A (0.55) | HTTACSS2MAPTRAB9A | |
| SCHEMBL12635694 | 0.84 | HTT (0.52) | HTTACSS2MAPTMEN1KMT2A | |
| SCHEMBL4036510 | 0.84 | S1PR1 (0.52) | HTTACSS2 | |
| SCHEMBL2018088 | 0.80 | TNF (0.53) | HTTACSS2MAPTMEN1KMT2A | |
| SCHEMBL2016331 | 0.79 | HTT (0.52) | HTTACSS2MAPTMEN1KMT2A | |
| SCHEMBL2492207 | 0.75 | HTT (0.45) | HTTACSS2MAPTMEN1KMT2A | |
| SCHEMBL2043795 | 0.74 | ACSS2 (0.49) | HTTACSS2MAPTMEN1KMT2A | |
| SCHEMBL7257387 | 0.74 | MAPT (0.60) | MAPTMEN1KMT2AKDM4ETHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |