Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24126297 | 0.98 | SIGMAR1 (0.46) | SIGMAR1KDM4ECYP1A2GAACYP2C9 | |
| SCHEMBL18248348 | 0.80 | SIGMAR1 (0.44) | SIGMAR1KDM4ECYP1A2GAACYP2C9 | |
| SCHEMBL18248327 | 0.80 | SIGMAR1 (0.44) | SIGMAR1KDM4ECYP1A2GAACYP2C9 | |
| SCHEMBL30775408 | 0.78 | KDM4E (0.61) | SIGMAR1POLBKDM4ETSHR | |
| SCHEMBL8275473 | 0.78 | SIGMAR1 (0.50) | SIGMAR1SMN1; SMN2KDM4ECYP1A2GAA | |
| SCHEMBL19983438 | 0.78 | SIGMAR1 (0.46) | SIGMAR1KDM4ECYP1A2GAACYP2C9 | |
| SCHEMBL2274356 | 0.78 | ALDH1A1 (0.59) | SIGMAR1SMN1; SMN2KDM4ECYP1A2CYP2C9 | |
| SCHEMBL7477665 | 0.78 | KDM4E (0.62) | SIGMAR1POLBKDM4ECYP1A2GAA | |
| SCHEMBL10085632 | 0.77 | SMN1; SMN2 (0.50) | POLBSMN1; SMN2TSHR | |
| SCHEMBL13798271 | 0.77 | TSHR (0.45) | POLBSMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541802-B1 | ALKYL SUBSTITUTED TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2025-01-01 | — | — | EP | disclosed |
| EP-3541792-B1 | TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2020-12-23 | — | — | EP | disclosed |
| WO-2018093576-A1 | ALKYL SUBSTITUTED TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2018-05-24 | — | — | WO | disclosed |