SCHEMBL20183771

SCHEMBL20183771

O=c1cc(Cl)c2cc([N+](=O)[O-])ccc2[nH]1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 2/20 0.58
CA9 Q16790 2/20 0.58
CTSV O60911 2/20 0.55
CTSL P07711 2/20 0.55
PARP1 P09874 2/20 0.55
GRIA1 P42261 1/20 0.51
GRIA2 P42262 1/20 0.51
GRIA3 P42263 1/20 0.51
GRIA4 P48058 1/20 0.51
MAPT P10636 4/20 0.51
ALDH1A1 P00352 3/20 0.51
MEN1 O00255 3/20 0.51
KMT2A Q03164 3/20 0.51
LMNA P02545 3/20 0.51
NPC1 O15118 1/20 0.51
HSP90AA1 P07900 1/20 0.51
RAB9A P51151 1/20 0.51
NPSR1 Q6W5P4 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
POLB P06746 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31169728 1.00 CA12 (0.58) CA12CA9CTSVCTSLPARP1
SCHEMBL3604526 0.87 PARP1 (0.58) CA12CA9CTSVCTSLPARP1
SCHEMBL30349881 0.82 MAPT (0.61) CA12CA9CTSVCTSLPARP1
SCHEMBL31081636 0.81 CA12 (0.58) CA12CA9CTSVCTSLPARP1
SCHEMBL4469615 0.81 CA12 (0.58) CA12CA9CTSVCTSLPARP1
SCHEMBL29540314 0.79 GABRA1 (0.70) CA12CA9CTSVCTSLPARP1
SCHEMBL155013 0.79 GABRA1 (0.70) CA12CA9CTSVCTSLPARP1
SCHEMBL8366377 0.78 CA12 (0.51) CA12CA9CTSVCTSLPARP1
SCHEMBL31254142 0.77 CTSV (0.60) CA12CA9CTSVCTSLPARP1
SCHEMBL28982709 0.77 ALDH1A1 (0.59) CA12CA9CTSVCTSLPARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4729127-A2 BCL6 INHIBITORS Cancer Research Technology Limited (GB) 2026-04-22 EP disclosed
US-20260042776-A1 BCL6 INHIBITORS CANCER RESEARCH TECH LTD (GB) 2026-02-12 US disclosed
US-12486285-B2 BCL6 inhibitors CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2025-12-02 US disclosed
EP-3630749-B9 2-QUINOLONE DERIVED INHIBITORS OF BCL6 CANCER RESEARCH TECH LTD (GB) 2024-05-29 EP disclosed
EP-4371562-A2 2-QUINOLONE DERIVED INHIBITORS OF BCL6 Cancer Research Technology Limited (GB) 2024-05-22 EP disclosed
EP-3630749-B1 2-QUINOLONE DERIVED INHIBITORS OF BCL6 CANCER RESEARCH TECH LTD (GB) 2024-01-10 EP disclosed
US-20230287003-A1 BCL6 INHIBITORS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2023-09-14 US disclosed
EP-4201939-A1 BCL6 INHIBITORS Cancer Research Technology Limited (GB) 2023-06-28 EP disclosed
EP-3774817-B1 BCL6 INHIBITORS CANCER RESEARCH TECH LTD (GB) 2022-12-07 EP disclosed
US-11512095-B2 BCL6 inhibitors THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) 2022-11-29 US disclosed
CN-112334475-A BCL6 inhibitor 癌症研究技术有限公司 2021-02-05 CN disclosed
EP-3327004-B1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND FUJIFILM CORP (JP) 2020-11-04 EP disclosed
US-10696637-B2 Nitrogen-containing heterocyclic compound FUJIFILM CORPORATION (JP) 2020-06-30 US disclosed
US-10633343-B2 2020-04-28 US disclosed
EP-3630749-A1 2-QUINOLONE DERIVED INHIBITORS OF BCL6 Cancer Research Technology Limited (GB) 2020-04-08 EP disclosed
EP-3563851-A1 ANTITUMOR AGENT AND BROMODOMAIN INHIBITOR FUJIFILM Corporation (JP) 2019-11-06 EP disclosed
US-20190314360-A1 ANTITUMOR AGENT AND BROMODOMAIN INHIBITOR FUJIFILM CORPORATION (JP) 2019-10-17 US disclosed
US-20190077761-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND FUJIFILM CORPORATION (JP) 2019-03-14 US disclosed
WO-2018215798-A1 2-QUINOLONE DERIVED INHIBITORS OF BCL6 CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2018-11-29 WO disclosed
EP-3327004-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND Fujifilm Corporation (JP) 2018-05-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230287003-A1 BCL6 INHIBITORS BCL6, BCL6B, BCL3 CA12 4340/4885CA9 3945/4885CTSV 2198/4885
US-10696637-B2 Nitrogen-containing heterocyclic compound CXCL10, CCL5, CXCR3 CA12 1029/4885CA9 1127/4885CTSV 4051/4885
US-12486285-B2 BCL6 inhibitors BCL6, BCL6B, BCL3 CA12 4340/4885CA9 3945/4885CTSV 2198/4885
US-20190314360-A1 ANTITUMOR AGENT AND BROMODOMAIN INHIBITOR BRD4, BRD1, BRD3 CA12 998/4885CA9 1004/4885CTSV 2049/4885
US-20190077761-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND CXCL10, CCL5, CXCR3 CA12 1029/4885CA9 1127/4885CTSV 4051/4885
US-11512095-B2 BCL6 inhibitors BCL6, BCL6B, BCL3 CA12 4340/4885CA9 3945/4885CTSV 2198/4885
US-20260042776-A1 BCL6 INHIBITORS BCL6, BCL6B, BCL9 CA12 4101/4885CA9 2157/4885CTSV 1898/4885
US-10633343-B2 CXCL10, CCL5, CXCR3 CA12 874/4885CA9 1121/4885CTSV 3207/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.