Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.52 |
| ▸ | USP7 | Q93009 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18400237 | 0.89 | BRD4 (0.58) | LMNAMAPK10HTR7P2RX7USP7 | |
| SCHEMBL22728032 | 0.74 | PDE4D (0.34) | — | |
| SCHEMBL646266 | 0.72 | LMNA (1.00) | LMNAMAPK10HTR7USP7MAPK1 | |
| SCHEMBL11622018 | 0.72 | LMNA (0.93) | LMNAMAPK10HTR7USP7BRD4 | |
| SCHEMBL11982661 | 0.71 | P2RX7 (0.52) | LMNAP2RX7MAPK1MAPTHPGD | |
| SCHEMBL16036558 | 0.71 | P2RX7 (0.78) | P2RX7BRD4CREBBP | |
| SCHEMBL17244880 | 0.71 | P2RX7 (0.66) | LMNAMAPK10P2RX7BRD4CREBBP | |
| SCHEMBL19941936 | 0.71 | USP7 (0.61) | LMNAMAPK10HTR7P2RX7USP7 | |
| SCHEMBL17347021 | 0.71 | USP7 (0.61) | LMNAMAPK10HTR7P2RX7USP7 | |
| SCHEMBL10095277 | 0.71 | CYP2C19 (0.71) | LMNAMAPK10HTR7USP7BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970267-B3 | P2X7 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-30 | — | — | EP | claimed |