Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 3/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34469152 | 0.76 | DPP4 (0.39) | — | |
| SCHEMBL17232727 | 0.75 | CYP2C19 (0.55) | CYP2C19 | |
| SCHEMBL20184301 | 0.74 | LMNA (0.55) | — | |
| SCHEMBL17232648 | 0.72 | EP300 (0.49) | — | |
| SCHEMBL17232760 | 0.72 | CYP2C9 (0.38) | CYP2C19 | |
| SCHEMBL17232729 | 0.71 | ALDH1A1 (0.39) | CYP2C19 | |
| SCHEMBL16118433 | 0.71 | RBP4 (0.38) | CYP2C19 | |
| SCHEMBL17232758 | 0.71 | CYP2C19 (0.35) | CYP2C19 | |
| SCHEMBL17232684 | 0.71 | CCNA2 (0.39) | — | |
| SCHEMBL17232737 | 0.71 | CYP2C9 (0.34) | CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3368539-B1 | SUBSTITUTED INDAZOLE COMPOUNDS AS ROR GAMMA T INHIBITORS AND USES THEREOF | MERCK SHARP & DOHME (US) | 2020-12-02 | — | — | EP | disclosed |