Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 4/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 11/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184322 | 0.90 | JAK3 (0.62) | JAK3MAOBJAK2 | |
| SCHEMBL20184588 | 0.88 | MMP2 (0.52) | JAK3TRPA1JAK2 | |
| SCHEMBL20184557 | 0.87 | JAK3 (0.47) | JAK3JAK2 | |
| SCHEMBL20184602 | 0.85 | JAK3 (0.52) | JAK3JAK2 | |
| SCHEMBL20184508 | 0.85 | JAK3 (0.59) | JAK3JAK2 | |
| SCHEMBL20184521 | 0.85 | JAK3 (0.59) | JAK3JAK2 | |
| SCHEMBL20184603 | 0.84 | JAK3 (0.63) | JAK3MAOBMCHR1TRPA1TRPM8 | |
| SCHEMBL20184370 | 0.84 | MMP1 (0.50) | JAK3JAK2 | |
| SCHEMBL20184704 | 0.84 | JAK3 (0.59) | JAK3JAK2 | |
| SCHEMBL20184539 | 0.84 | JAK3 (0.51) | JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |