Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 9/20 | 0.52 |
| ▸ | JAK2 | O60674 | 3/20 | 0.46 |
| ▸ | NAMPT | P43490 | 8/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184322 | 0.91 | JAK3 (0.62) | JAK3JAK2 | |
| SCHEMBL20184370 | 0.86 | MMP1 (0.50) | JAK3JAK2NPC1RAB9A | |
| SCHEMBL20184588 | 0.85 | MMP2 (0.52) | JAK3JAK2NPC1RAB9A | |
| SCHEMBL20184521 | 0.85 | JAK3 (0.59) | JAK3JAK2 | |
| SCHEMBL20184508 | 0.85 | JAK3 (0.59) | JAK3JAK2 | |
| SCHEMBL20184418 | 0.85 | JAK3 (0.64) | JAK3JAK2 | |
| SCHEMBL20184526 | 0.85 | JAK3 (0.51) | JAK3JAK2 | |
| SCHEMBL20184539 | 0.85 | JAK3 (0.51) | JAK3JAK2 | |
| SCHEMBL20184704 | 0.85 | JAK3 (0.59) | JAK3JAK2 | |
| SCHEMBL20184590 | 0.84 | JAK3 (0.64) | JAK3JAK2NAMPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |