Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 14/20 | 0.48 |
| ▸ | JAK2 | O60674 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16245235 | 0.87 | JAK3 (0.62) | JAK3JAK2ALDH1A1LMNANPC1 | |
| SCHEMBL20184497 | 0.86 | HSP90AB1 (0.36) | JAK3JAK2HSP90AB1IKBKBCHUK | |
| SCHEMBL20184324 | 0.84 | JAK3 (0.59) | JAK3JAK2JAK1 | |
| SCHEMBL20184520 | 0.83 | JAK3 (0.41) | JAK3JAK2JAK1 | |
| SCHEMBL16245236 | 0.81 | JAK3 (0.39) | JAK3JAK2HSP90AB1JAK1 | |
| SCHEMBL20184677 | 0.80 | F11 (0.43) | JAK3JAK2HSP90AB1IKBKBCHUK | |
| SCHEMBL20184688 | 0.80 | JAK3 (0.43) | JAK3JAK2JAK1 | |
| SCHEMBL20184694 | 0.79 | JAK3 (0.47) | JAK3JAK2JAK1 | |
| SCHEMBL20184323 | 0.78 | JAK3 (0.41) | JAK3JAK2JAK1 | |
| SCHEMBL20184522 | 0.78 | JAK3 (0.37) | JAK3JAK2HSP90AB1IKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |