Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 5/20 | 0.35 |
| ▸ | IKBKB | O14920 | 3/20 | 0.35 |
| ▸ | JAK3 | P52333 | 11/20 | 0.35 |
| ▸ | JAK2 | O60674 | 9/20 | 0.35 |
| ▸ | EIF4E | P06730 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184465 | 0.86 | JAK3 (0.45) | JAK3JAK2 | |
| SCHEMBL20184604 | 0.86 | JAK3 (0.36) | JAK3JAK2 | |
| SCHEMBL20184344 | 0.86 | JAK3 (0.48) | HSP90AB1CHUKIKBKBJAK3JAK2 | |
| SCHEMBL20184371 | 0.83 | JAK3 (0.45) | JAK3JAK2 | |
| SCHEMBL20184677 | 0.83 | F11 (0.43) | HSP90AB1CHUKIKBKBJAK3JAK2 | |
| SCHEMBL20184522 | 0.83 | JAK3 (0.37) | HSP90AB1CHUKIKBKBJAK3JAK2 | |
| SCHEMBL20184551 | 0.79 | JAK3 (0.53) | JAK3JAK2 | |
| SCHEMBL20184548 | 0.79 | JAK3 (0.53) | CHUKIKBKBJAK3JAK2 | |
| SCHEMBL20184525 | 0.78 | JAK2 (0.49) | CHUKJAK3JAK2 | |
| SCHEMBL20184532 | 0.78 | PRKD1 (0.40) | HSP90AB1JAK3JAK2CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | disclosed |