Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.45 |
| ▸ | JAK2 | O60674 | 8/20 | 0.43 |
| ▸ | JAK3 | P52333 | 8/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SGK1 | O00141 | 1/20 | 0.39 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GRK6 | P43250 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184593 | 0.88 | GPR84 (0.48) | GPR84JAK2JAK3 | |
| SCHEMBL20184673 | 0.87 | JAK2 (0.53) | JAK2JAK3KDM4EALDH1A1 | |
| SCHEMBL20184489 | 0.86 | JAK2 (0.51) | GPR84JAK2JAK3SGK1CAMKK2 | |
| SCHEMBL20184337 | 0.86 | JAK2 (0.43) | JAK2JAK3KDM4EALDH1A1 | |
| SCHEMBL20184527 | 0.86 | JAK2 (0.49) | JAK2JAK3SGK1CAMKK2 | |
| SCHEMBL20184525 | 0.86 | JAK2 (0.49) | GPR84JAK2JAK3KDM4ESGK1 | |
| SCHEMBL20184517 | 0.85 | CYP3A4 (0.40) | JAK2JAK3KDM4EALDH1A1MAPK1 | |
| SCHEMBL20184555 | 0.85 | HSP90AB1 (0.43) | JAK2JAK3SGK1CAMKK2 | |
| SCHEMBL20184700 | 0.85 | JAK2 (0.40) | JAK2JAK3 | |
| SCHEMBL20184538 | 0.83 | JAK2 (0.39) | JAK2JAK3SGK1CAMKK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | disclosed |