Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.48 |
| ▸ | JAK3 | P52333 | 9/20 | 0.44 |
| ▸ | JAK2 | O60674 | 8/20 | 0.44 |
| ▸ | NEK1 | Q96PY6 | 3/20 | 0.43 |
| ▸ | AXL | P30530 | 2/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184417 | 0.88 | DYRK1A (0.45) | JAK3JAK2AXLCDK8 | |
| SCHEMBL20184387 | 0.88 | GPR84 (0.45) | GPR84JAK3JAK2 | |
| SCHEMBL20184518 | 0.87 | PRKAB2 (0.48) | JAK3JAK2 | |
| SCHEMBL20184548 | 0.86 | JAK3 (0.53) | JAK3JAK2 | |
| SCHEMBL20184551 | 0.86 | JAK3 (0.53) | JAK3JAK2 | |
| SCHEMBL20184525 | 0.85 | JAK2 (0.49) | GPR84JAK3JAK2AXL | |
| SCHEMBL20184478 | 0.85 | JAK2 (0.53) | JAK3JAK2 | |
| SCHEMBL20184581 | 0.85 | JAK3 (0.43) | JAK3JAK2 | |
| SCHEMBL20184599 | 0.85 | JAK3 (0.53) | JAK3JAK2 | |
| SCHEMBL20184383 | 0.84 | JAK3 (0.49) | JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |