Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAD | P27708 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | METAP2 | P50579 | 8/20 | 0.38 |
| ▸ | METAP1 | P53582 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28804446 | 0.85 | EPHX1 (0.49) | TSHR | |
| SCHEMBL27654640 | 0.83 | CAD (0.55) | CADTSHRMETAP2METAP1ALDH1A1 | |
| SCHEMBL5813322 | 0.82 | GAA (0.43) | TSHRMETAP2METAP1ALDH1A1NPSR1 | |
| SCHEMBL5813330 | 0.82 | GAA (0.43) | TSHRMETAP2METAP1ALDH1A1NPSR1 | |
| SCHEMBL27286440 | 0.82 | CAD (0.41) | CADTSHRALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL20187916 | 0.81 | TSHR (0.37) | CADTSHRMETAP2METAP1ALDH1A1 | |
| SCHEMBL28544834 | 0.78 | HCAR2 (0.37) | TSHRMETAP2METAP1ALDH1A1MAPK1 | |
| SCHEMBL15043976 | 0.78 | CA14 (0.50) | CADTSHRALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL22822298 | 0.78 | CA14 (0.50) | CADTSHRALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL10055358 | 0.78 | CA14 (0.50) | CADTSHRALDH1A1MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3544635-A2 | PEPTIDE-CONTAINING LINKERS FOR ANTIBODY-DRUG CONJUGATES | Mersana Therapeutics, Inc. (US) | 2019-10-02 | — | — | EP | disclosed |
| WO-2018098269-A2 | PEPTIDE-CONTAINING LINKERS FOR ANTIBODY-DRUG CONJUGATES | MERSANA THERAPEUTICS, INC. (US) | 2018-05-31 | — | — | WO | disclosed |