Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 6/20 | 0.34 |
| ▸ | CAD | P27708 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | METAP2 | P50579 | 3/20 | 0.32 |
| ▸ | METAP1 | P53582 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ALPG | P10696 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.31 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28804446 | 0.82 | EPHX1 (0.49) | TSHRACHE | |
| SCHEMBL20188172 | 0.81 | CAD (0.40) | TSHRCADNPSR1RAB9AMAPT | |
| SCHEMBL18669008 | 0.78 | ACHE (0.41) | TSHRACHENPSR1ALDH1A1 | |
| SCHEMBL18669010 | 0.78 | ACHE (0.41) | TSHRACHENPSR1ALDH1A1 | |
| SCHEMBL27654640 | 0.76 | CAD (0.55) | TSHRCADMETAP2METAP1ALDH1A1 | |
| SCHEMBL15043976 | 0.75 | CA14 (0.50) | TSHRMEN1KMT2ACADMAPT | |
| SCHEMBL10055358 | 0.75 | CA14 (0.50) | TSHRMEN1KMT2ACADMAPT | |
| SCHEMBL22822298 | 0.75 | CA14 (0.50) | TSHRMEN1KMT2ACADMAPT | |
| SCHEMBL4671001 | 0.74 | ACHE (0.35) | ACHEMAPTALDH1A1 | |
| SCHEMBL20591068 | 0.74 | CHRNB2 (0.35) | ACHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3544635-A2 | PEPTIDE-CONTAINING LINKERS FOR ANTIBODY-DRUG CONJUGATES | Mersana Therapeutics, Inc. (US) | 2019-10-02 | — | — | EP | disclosed |
| CN-110234357-A | Contain peptide linker for antibody-drug conjugates | 梅尔莎纳医疗公司 | 2019-09-13 | — | — | CN | disclosed |
| WO-2018098269-A2 | PEPTIDE-CONTAINING LINKERS FOR ANTIBODY-DRUG CONJUGATES | MERSANA THERAPEUTICS, INC. (US) | 2018-05-31 | — | — | WO | disclosed |