Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | CCR8 | P51685 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | APLNR | P35414 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3922703 | 0.76 | APLNR (0.44) | APLNR | |
| SCHEMBL29956303 | 0.76 | L3MBTL1 (0.32) | KDM4E | |
| SCHEMBL3407215 | 0.76 | ALDH1A1 (0.39) | KDM4E | |
| SCHEMBL622632 | 0.72 | — | — | |
| SCHEMBL4033509 | 0.71 | CCR1 (0.43) | MAPTRAB9ACCR1CCR5CCR8 | |
| SCHEMBL18648926 | 0.71 | CCR1 (0.39) | CCR1CCR5CCR8HDAC6APLNR | |
| SCHEMBL11702945 | 0.70 | — | — | |
| Hydrochloric Acid SCHEMBL247415 | 0.70 | CCR1 (0.41) | MAPTRAB9ACCR1CCR5CCR8 | |
| SCHEMBL2937160 | 0.69 | — | — | |
| SCHEMBL2175860 | 0.68 | GABRA1 (0.32) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541792-A1 | TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | Amgen Inc. (US) | 2019-09-25 | — | — | EP | disclosed |
| WO-2018097944-A1 | TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2018-05-31 | — | — | WO | disclosed |