SCHEMBL20189884

SCHEMBL20189884

Fc1cc(Br)cnc1OC1CC(F)(F)C1

nearest known ligand 0.46

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.46
ACACB O00763 13/20 0.33
EPAS1 Q99814 1/20 0.33
HSD11B1 P28845 2/20 0.30
FPR2 P25090 1/20 0.30
PROKR1 Q8TCW9 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30448458 1.00 CYP1A2 (0.46) CYP1A2ACACBEPAS1HSD11B1FPR2
SCHEMBL31087500 0.83 ACACB (0.38) ACACBFPR2PROKR1
SCHEMBL26602975 0.83 ACACB (0.38) ACACBFPR2PROKR1
SCHEMBL16858563 0.83 CYP1A2 (0.36) CYP1A2ACACBEPAS1
SCHEMBL22711938 0.79 CYP1A2 (0.31) CYP1A2
SCHEMBL30856679 0.74 KMT2A (0.41) EPAS1
SCHEMBL22711889 0.74 MBOAT4 (0.33) ACACB
SCHEMBL29195489 0.74 KMT2A (0.41) EPAS1
SCHEMBL20190609 0.73 CYP1A2 (0.41) CYP1A2ACACB
SCHEMBL22711853 0.72 DGAT1 (0.43) ACACBEPAS1HSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250376475-A1 ION CHANNEL MODULATORS PRAXIS PREC MEDICINES INC (US) 2025-12-11 US disclosed
US-20250163068-A1 COMPOUNDS AND THEIR METHODS OF USE PRAXIS PRECISION MEDICINES, INC. 2025-05-22 US disclosed
EP-4487916-A2 ION CHANNEL MODULATORS Praxis Precision Medicines, Inc. (US) 2025-01-08 EP disclosed
EP-4397308-A2 COMPOUNDS AND THEIR METHODS OFUSE Praxis Precision Medicines, Inc. (US) 2024-07-10 EP disclosed
US-20240132501-A1 ION CHANNEL MODULATORS PRAXIS PRECISION MEDICINES, INC. (US) 2024-04-25 US disclosed
EP-3548033-B1 COMPOUNDS AND THEIR METHODS OF USE PRAXIS PREC MEDICINES INC (US) 2024-04-10 EP disclosed
CN-117756800-A Ion channel modulators 普拉克西斯精密药物股份有限公司 2024-03-26 CN disclosed
US-11918571-B2 Compounds and their methods of use PRAXIS PRECISION MEDICINES, INC. (US) 2024-03-05 US disclosed
US-11866439-B2 Ion channel modulators PRAXIS PRECISION MEDICINES, INC. (US) 2024-01-09 US disclosed
US-20230322790-A1 COMPOUNDS AND THEIR METHODS OF USE PRAXIS PRECISION MEDICINES, INC. 2023-10-12 US disclosed
US-20210163488-A1 ION CHANNEL MODULATORS PRAXIS PRECISION MEDICINES, INC. 2021-06-03 US disclosed
US-11014931-B2 3-(ethoxydifluoromethyl)-6-(5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-[1,2,4]triazolo[4,3-a]pyrazine as an ion channel modulator PRAXIS PRECISION MEDICINES, INC. (US) 2021-05-25 US disclosed
EP-3801535-A1 ION CHANNEL MODULATORS Praxis Precision Medicines, Inc. (US) 2021-04-14 EP disclosed
US-20210087197-A1 ION CHANNEL MODULATORS PRAXIS PRECISION MEDICINES, INC. 2021-03-25 US disclosed
CN-112423760-A Ion channel modulators 普拉克西斯精密药物股份有限公司 2021-02-26 CN disclosed
US-20200179358-A1 COMPOUNDS AND THEIR METHODS OF USE PRAXIS PRECISION MEDICINES, INC. 2020-06-11 US disclosed
EP-3548033-A1 COMPOUNDS AND THEIR METHODS OF USE Praxis Precision Medicines, Inc. (US) 2019-10-09 EP disclosed
WO-2019035951-A1 COMPOUNDS AND THEIR METHODS OF USE PRAXIS PRECISION MEDICINES, INC. (US) 2019-02-21 WO disclosed
WO-2018098499-A1 COMPOUNDS AND THEIR METHODS OF USE PRAXIS PRECISION MEDICINES, INC. (US) 2018-05-31 WO disclosed
WO-2018098499-A1 COMPOUNDS AND THEIR METHODS OF USE PRAXIS PRECISION MEDICINES, INC. (US) 2018-05-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11918571-B2 Compounds and their methods of use SCN1A, SCN3A, SCN2A CYP1A2 2676/4885ACACB 901/4885EPAS1 2793/4885
US-20240132501-A1 ION CHANNEL MODULATORS SCN1A, SCN3A, SCN2A CYP1A2 2873/4885ACACB 2004/4885EPAS1 2556/4885
US-20210087197-A1 ION CHANNEL MODULATORS SCN1A, SCN3A, SCN2A CYP1A2 2873/4885ACACB 2004/4885EPAS1 2556/4885
US-11866439-B2 Ion channel modulators SCN1A, SCN3A, SCN2A CYP1A2 2873/4885ACACB 2004/4885EPAS1 2556/4885
US-20210163488-A1 ION CHANNEL MODULATORS SCN1A, SCN3A, SCN2A CYP1A2 2873/4885ACACB 2004/4885EPAS1 2556/4885
US-20250163068-A1 COMPOUNDS AND THEIR METHODS OF USE SCN1A, SCN3A, SCN1B CYP1A2 1988/4885ACACB 814/4885EPAS1 2711/4885
US-11014931-B2 3-(ethoxydifluoromethyl)-6-(5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-[1,2,4]triazolo[4,3-a]pyrazine as an ion channel modulator SCN3A, SCN1A, SCN5A CYP1A2 2631/4885ACACB 3534/4885EPAS1 1867/4885
US-20250376475-A1 ION CHANNEL MODULATORS SCN1A, SCN3A, SCN2A CYP1A2 2873/4885ACACB 2004/4885EPAS1 2556/4885
US-20200179358-A1 COMPOUNDS AND THEIR METHODS OF USE SCN1A, SCN3A, SCN2A CYP1A2 2676/4885ACACB 901/4885EPAS1 2793/4885
US-20230322790-A1 COMPOUNDS AND THEIR METHODS OF USE SCN1A, SCN3A, SCN1B CYP1A2 1988/4885ACACB 814/4885EPAS1 2711/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.