Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nicotine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 known ✓ | P17787 | 4/20 | 1.00 |
| ▸ | CHRNA4 known ✓ | P43681 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 1.00 |
| ▸ | CHRNA7 | P36544 | 4/20 | 1.00 |
| ▸ | CHRNB4 | P30926 | 3/20 | 1.00 |
| ▸ | CHRNA3 | P32297 | 3/20 | 1.00 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 1.00 |
| ▸ | PSIP1 | O75475 | 1/20 | 1.00 |
| ▸ | TRPA1 | O75762 | 1/20 | 1.00 |
| ▸ | HTR3B | O95264 | 1/20 | 1.00 |
| ▸ | CHRNA1 | P02708 | 1/20 | 1.00 |
| ▸ | CHRNG | P07510 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | CHRNB1 | P11230 | 1/20 | 1.00 |
| ▸ | CYP2A6 | P11509 | 1/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 1/20 | 1.00 |
| ▸ | CHRNA5 | P30532 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (+/-)Nicotine SCHEMBL20193 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| R-Nicotine SCHEMBL20518 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL10909351 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL308101 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL11976729 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL4729900 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL10909353 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL1724652 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL2599622 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL797620 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 230668 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260144300-A1 | NON-NICOTINE ELECTRONIC VAPING DEVICES HAVING DRYNESS DETECTION AND AUTO SHUTDOWN | ALTRIA CLIENT SERVICES LLC (US) | 2026-05-28 | — | — | US | claimed |
| US-20260144284-A1 | ORAL POUCH COMPRISING A POUCH ENVELOPE MADE OF A CHEMICALLY BONDED NONWOVEN FABRIC AND A FILLING MATERIAL ARRANGED THEREIN | PELY-TEX GMBH & CO. KG (DE) | 2026-05-28 | — | — | US | claimed |
| US-20260144781-A1 | COMPOSITION AND METHOD FOR CONTROLLED HUMAN NICOTINE ABSORPTION WITHOUT PH ADJUSTERS | NIC NAC NATURALS, LLC (US) | 2026-05-28 | — | — | US | claimed |
| US-20260148852-A1 | ORGANIC MOLECULE EXPOSOMICS | LINUS BIOTECHNOLOGY INC. (US) | 2026-05-28 | — | — | US | claimed |
| US-20260144291-A1 | APPARATUS FOR SECURING A BEVERAGE CAN TO A CONTAINER | BLOCK, Austin Ray (US) | 2026-05-28 | — | — | US | claimed |
| US-20260144773-A1 | METHODS OF REDUCING PHYSICAL DEPENDENCE TO NEUROPSYCHIATRIC TREATMENTS | SUMITOMO PHARMA AMERICA, INC. (US) | 2026-05-28 | — | — | US | claimed |
| EP-4748444-A2 | COMPOSITIONS COMPRISING CYTISINE IN THE TREATMENT AND/OR PREVENTION OF ADDICTION IN SUBJECTS IN NEED THEREOF | Achieve Life Sciences, Inc. (US) | 2026-05-27 | — | — | EP | claimed |
| EP-3873241-B1 | AEROSOLISABLE FORMULATION | NICOVENTURES TRADING LTD (GB) | 2026-05-27 | — | — | EP | claimed |
| EP-4746725-A1 | NICOTINE COMPOSITION WITH IMPROVED STABILITY AND TOXICOLOGY | Steinbauer, Martin (AT) | 2026-05-27 | — | — | EP | claimed |
| EP-4747587-A1 | LIQUID METERING DISPENSING APPARATUS AND METHOD OF OPERATING THEREOF | Athos Medical Technology Ltd (GB) | 2026-05-27 | — | — | EP | claimed |
| US-4058457-A | Recovery of activated carbon | MANES MILTON | 1977-11-15 | — | — | US | claimed |
| US-4049005-A | Filtering apparatus for cigarette smokers | HERNANDEZ ARMANDO C | 1977-09-20 | — | — | US | claimed |
| US-4038993-A | 3-SUCCINOYL PYRIDINE | BROWN & WILLIAMSON TOBACCO CORPORATION (US) | 1977-08-02 | — | — | US | claimed |
| US-4037609-A | FORMING 3-SUCCINOYL-PYRIDINE | BROWN & WILLIAMSON TOBACCO CORPORATION (US) | 1977-07-26 | — | — | US | claimed |
| US-4034768-A | Non fibrous cigarette filter | JOYCE PATRICK J | 1977-07-12 | — | — | US | claimed |
| US-4011141-A | PROCESS FOR MAXIMIZING THE GROWTH AND NICOTINE DEGRADING ACTIVITY OF MICROORGANISMS | BROWN & WILLIAMSON TOBACCO CORPORATION (US) | 1977-03-08 | — | — | US | claimed |
| US-4009722-A | Method and machine for making cigarettes with composite fillers | HAUNI-WERKE KORBER & CO., KG (DT) | 1977-03-01 | — | — | US | claimed |
| US-4006749-A | GRAFT POLYMERS, NICOTINE, PYRIDINE BASES | CONSOLIDATED CIGAR CORPORATION (US) | 1977-02-08 | — | — | US | claimed |
| US-3989823-A | COMBATING SMOKING | COSTANZO FRANCOIS DI | 1976-11-02 | — | — | US | claimed |
| US-3943940-A | Method of removing nicotine in smoking and a smoking filter to be used therefor | MINAMI ISAO | 1976-03-16 | — | — | US | claimed |