Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Pimelic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.57 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.52 |
| ▸ | KDM4A | O75164 | 2/20 | 0.52 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.52 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.52 |
| ▸ | TET3 | O43151 | 1/20 | 0.52 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 6/20 | 0.46 |
| ▸ | PPARD | Q03181 | 6/20 | 0.46 |
| ▸ | PPARA | Q07869 | 6/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TLR2 | O60603 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL2019308 | 0.98 | SMN1; SMN2 (0.75) | SMN1; SMN2TSHRLMNANFKB1PMP22 | |
| Adipic Acid SCHEMBL28234949 | 0.95 | SMN1; SMN2 (0.71) | SMN1; SMN2TSHRLMNANFKB1PMP22 | |
| Malic Acid SCHEMBL7895521 | 0.93 | SMN1; SMN2 (0.75) | SMN1; SMN2TSHRLMNANFKB1PMP22 | |
| Cadaverine Tartrate SCHEMBL27687433 | 0.91 | SMN1; SMN2 (0.65) | SMN1; SMN2TSHRLMNANFKB1PMP22 | |
| Octanoic Acid SCHEMBL31240956 | 0.90 | GPR84 (0.65) | SMN1; SMN2TSHRGPR84FFAR1FFAR4 | |
| Stearic Acid SCHEMBL3379301 | 0.90 | GPR84 (0.65) | SMN1; SMN2TSHRGPR84FFAR1FFAR4 | |
| Behenic Acid SCHEMBL28358122 | 0.90 | GPR84 (0.65) | SMN1; SMN2TSHRGPR84FFAR1FFAR4 | |
| Palmitic Acid SCHEMBL15066461 | 0.88 | GPR84 (0.63) | SMN1; SMN2TSHRGPR84FFAR1FFAR4 | |
| Malic Acid SCHEMBL4814892 | 0.87 | SMN1; SMN2 (0.83) | SMN1; SMN2LMNATET2KDM4AKDM4C | |
| Malic Acid SCHEMBL28105083 | 0.87 | SMN1; SMN2 (0.83) | SMN1; SMN2LMNATET2KDM4AKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100055232-A1 | DEGRADABLE CHEWING GUM | IDAR MEDICAL BIODEGRADABLE AB | 2010-03-04 | — | — | US | disclosed |
| EP-2096938-A2 | DEGRADABLE CHEWING GUM | Idar Medical Biodegradable AB (SE) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008068641-A2 | DEGRADABLE CHEWING GUM | IDAR MEDICAL BIODEGRADABLE AB (US) | 2008-06-12 | — | — | WO | disclosed |