Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 4/20 | 0.49 |
| ▸ | MMP13 | P45452 | 4/20 | 0.49 |
| ▸ | MMP3 | P08254 | 3/20 | 0.49 |
| ▸ | MMP7 | P09237 | 3/20 | 0.49 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.49 |
| ▸ | CAPN1 | P07384 | 4/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.44 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20349859 | 1.00 | ALDH1A1 (0.52) | ALDH1A1ITGA4MMP1MMP13MMP3 | |
| SCHEMBL5351635 | 0.94 | ALDH1A1 (0.51) | ALDH1A1ITGA4MMP1MMP13MMP3 | |
| SCHEMBL20349899 | 0.94 | ALDH1A1 (0.51) | ALDH1A1ITGA4MMP1MMP13MMP3 | |
| SCHEMBL20349905 | 0.94 | ALDH1A1 (0.53) | ALDH1A1ITGA4MMP1MMP13MMP3 | |
| SCHEMBL20349851 | 0.92 | FKBP1A (0.49) | ALDH1A1ITGA4MMP1MMP13MMP3 | |
| SCHEMBL20349862 | 0.91 | ALDH1A1 (0.53) | ALDH1A1ITGA4MMP1MMP13MMP3 | |
| SCHEMBL20349847 | 0.91 | ALDH1A1 (0.53) | ALDH1A1ITGA4MMP1MMP13MMP3 | |
| SCHEMBL20349850 | 0.91 | ALDH1A1 (0.50) | ALDH1A1ITGA4MMP1MMP13MMP3 | |
| SCHEMBL20349846 | 0.91 | ALDH1A1 (0.50) | ALDH1A1ITGA4MMP1MMP13MMP3 | |
| SCHEMBL28797859 | 0.91 | ALDH1A1 (0.50) | ALDH1A1ITGA4MMP1MMP13MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10335417-B2 | Thiazideamide derivative and use thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2019-07-02 | — | — | US | disclosed |
| US-20180185376-A1 | Thiazideamide Derivative and Use Thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2018-07-05 | — | — | US | disclosed |
| EP-3327010-A1 | THIAZIDEAMIDE DERIVATIVE AND USE THEREOF | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China (CN) | 2018-05-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10335417-B2 | Thiazideamide derivative and use thereof | TREH, AQP4, TST | ALDH1A1 1305/4885ITGA4 4546/4885MMP1 1369/4885 |
| US-20180185376-A1 | Thiazideamide Derivative and Use Thereof | TREH, AQP4, TST | ALDH1A1 1305/4885ITGA4 4546/4885MMP1 1369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.