Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 5/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | STAT6 | P42226 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2019895 | 0.86 | HTT (0.44) | HTTHDAC6PPARGLMNACYP1A2 | |
| Iodide SCHEMBL2019374 | 0.85 | HTT (0.43) | HTTHDAC6PPARGLMNACYP1A2 | |
| SCHEMBL2019532 | 0.85 | HDAC6 (0.49) | HTTGAAHDAC6PPARGHPGD | |
| SCHEMBL2015349 | 0.83 | HTT (0.57) | HTTGAALMNAHPGDSMN1; SMN2 | |
| SCHEMBL2018490 | 0.83 | KDM4E (0.53) | HTTHDAC6KDM4EALDH1A1RECQL | |
| SCHEMBL2014471 | 0.82 | MAPT (0.52) | HTTGAAHDAC6HPGDKDM4E | |
| SCHEMBL2040435 | 0.82 | HTT (0.45) | HTTGAALMNACYP1A2SMN1; SMN2 | |
| SCHEMBL2014103 | 0.81 | SCNN1A (0.43) | HTTGAAHDAC6PPARGSMN1; SMN2 | |
| SCHEMBL2014823 | 0.81 | HTT (0.45) | HTTLMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2016331 | 0.81 | HTT (0.52) | HTTGAALMNAHPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |