SCHEMBL2017836 — predicted protein targets

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	HTT	P42858	1/20	0.46

▸	ACSS2	Q9NR19	9/20	0.43

▸	MEN1	O00255	2/20	0.41

▸	KMT2A	Q03164	2/20	0.41

▸	HDAC6	Q9UBN7	1/20	0.41

▸	ALDH1A1	P00352	1/20	0.40

▸	FGB	P02675	1/20	0.40

▸	POLB	P06746	1/20	0.40

▸	THRB	P10828	1/20	0.40

▸	RECQL	P46063	1/20	0.40

▸	SCNN1A	P37088	1/20	0.40

▸	TP53	P04637	2/20	0.40

▸	LMNA	P02545	1/20	0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL2019532	0.92	HDAC6 (0.49)	HTTMEN1KMT2AHDAC6ALDH1A1
SCHEMBL2020396	0.92	HTT (0.48)	HTTACSS2MEN1KMT2AHDAC6
SCHEMBL12635756	0.91	HTT (0.49)	HTTACSS2MEN1KMT2AHDAC6
SCHEMBL2020165	0.91	ACSS2 (0.46)	HTTACSS2MEN1KMT2AHDAC6
SCHEMBL2040435	0.89	HTT (0.45)	HTTACSS2MEN1KMT2AALDH1A1
SCHEMBL2021620	0.89	HTT (0.45)	HTTACSS2MEN1KMT2AALDH1A1
SCHEMBL12636656	0.89	HTT (0.41)	HTTACSS2MEN1KMT2AHDAC6
SCHEMBL2014823	0.88	HTT (0.45)	HTTMEN1KMT2ASCNN1ATP53
SCHEMBL2016331	0.88	HTT (0.52)	HTTACSS2MEN1KMT2AALDH1A1
SCHEMBL2017078	0.88	HTT (0.41)	HTTACSS2MEN1KMT2AHDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2011079087-A1	ENAC BLOCKERS	GLAXO GROUP LIMITED (GB)	2011-06-30	—	—	WO	disclosed
WO-2011079087-A1	ENAC BLOCKERS	GLAXO GROUP LIMITED (GB)	2011-06-30	—	—	WO	disclosed