Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2021620 | 0.93 | HTT (0.45) | MAPTNPC1NLRP3NPSR1HTT | |
| SCHEMBL2018490 | 0.93 | KDM4E (0.53) | MAPTNPC1NLRP3NPSR1HTT | |
| SCHEMBL17937045 | 0.90 | HDAC6 (0.43) | MAPTNPC1NLRP3NPSR1HTT | |
| SCHEMBL2019532 | 0.89 | HDAC6 (0.49) | MAPTHTTHSD17B10ALDH1A1HPGD | |
| SCHEMBL2020165 | 0.85 | ACSS2 (0.46) | HTTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL2019384 | 0.84 | HTT (0.41) | MAPTNPC1NLRP3NPSR1HTT | |
| SCHEMBL2019895 | 0.84 | HTT (0.44) | HTTHSD17B10KMT2AMEN1HDAC6 | |
| Iodide SCHEMBL2019374 | 0.83 | HTT (0.43) | HTTHSD17B10KMT2AMEN1HDAC6 | |
| SCHEMBL2015349 | 0.82 | HTT (0.57) | HTTHPGDKMT2AMEN1GAA | |
| SCHEMBL2016173 | 0.82 | HTT (0.42) | HTTHSD17B10ALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |