Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31435157 | 0.82 | HDAC6 (0.50) | HDAC6HDAC1HDAC8OPRK1CYP2C9 | |
| SCHEMBL6305485 | 0.81 | ALDH1A1 (0.58) | HDAC6HDAC1HDAC8OPRK1CYP2C9 | |
| SCHEMBL4107301 | 0.81 | ALDH1A1 (0.58) | HDAC6HDAC1HDAC8OPRK1CYP2C9 | |
| SCHEMBL8576437 | 0.78 | OPRK1 (0.54) | HDAC6HDAC1HDAC8OPRK1CYP2C9 | |
| SCHEMBL8576433 | 0.78 | OPRK1 (0.54) | HDAC6HDAC1HDAC8OPRK1CYP2C9 | |
| SCHEMBL874399 | 0.78 | HDAC6 (0.48) | HDAC6HDAC1HDAC8OPRK1CYP2C9 | |
| SCHEMBL6344615 | 0.78 | HDAC6 (0.48) | HDAC6HDAC1HDAC8OPRK1CYP2C9 | |
| SCHEMBL874400 | 0.78 | HDAC6 (0.48) | HDAC6HDAC1HDAC8OPRK1CYP2C9 | |
| SCHEMBL1714279 | 0.76 | OPRK1 (0.59) | HDAC6HDAC1HDAC8OPRK1POLB | |
| SCHEMBL6343378 | 0.76 | OPRK1 (0.59) | HDAC6HDAC1HDAC8OPRK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110130382-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130382-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | HTR4, HTR1A, HTR1D | HDAC6 2270/4885HDAC1 1157/4885HDAC8 1493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.