Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.31 |
| ▸ | EIF4E | P06730 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20197238 | 0.82 | CYP19A1 (0.44) | CYP19A1AMY1AKDM4ENPC1CRHBP | |
| SCHEMBL16535582 | 0.81 | KDM1A (0.36) | CYP19A1AMY1AKDM4ENPC1CRHBP | |
| SCHEMBL20197304 | 0.80 | CDK2 (0.39) | CYP19A1AMY1AKDM4ENPC1CRHBP | |
| SCHEMBL20197337 | 0.77 | CYP1A2 (0.40) | CYP19A1KDM4ENPC1CRHBPRAB9A | |
| SCHEMBL20197235 | 0.76 | SREBF2 (0.42) | KDM4E | |
| SCHEMBL20197301 | 0.76 | KDM4E (0.34) | CYP19A1KDM4ENPC1CRHBPRAB9A | |
| SCHEMBL20197481 | 0.76 | EIF4E (0.37) | KDM4ENPC1CRHBPRAB9ACRHR2 | |
| SCHEMBL20197443 | 0.76 | C1S (0.39) | CYP19A1AMY1AKDM4ENPC1CRHBP | |
| SCHEMBL20197223 | 0.76 | SREBF2 (0.42) | KDM4E | |
| SCHEMBL20197368 | 0.76 | MAPK14 (0.35) | KDM4ENPC1CRHBPRAB9ACRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3038622-B1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | MEDIVATION TECH LLC (US) | 2018-05-30 | — | — | EP | disclosed |