Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | EIF4E | P06730 | 12/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.33 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16535716 | 0.86 | PPARA (0.38) | KDM4ESMN1; SMN2NPC1RAB9ACRHBP | |
| SCHEMBL22152727 | 0.77 | SREBF2 (0.43) | KDM4ELMNAMAPTALDH1A1 | |
| SCHEMBL20197302 | 0.77 | SMN1; SMN2 (0.46) | KDM4ESMN1; SMN2NPC1RAB9ACRHBP | |
| SCHEMBL20197240 | 0.75 | ALDH1A1 (0.53) | KDM4ESMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL20197292 | 0.74 | SMN1; SMN2 (0.33) | SMN1; SMN2MEN1KMT2ALMNAMAPT | |
| SCHEMBL20197471 | 0.73 | C1S (0.35) | KDM4ESMN1; SMN2NPC1RAB9ACRHBP | |
| SCHEMBL20197440 | 0.73 | KDM4E (0.36) | KDM4ESMN1; SMN2NPC1RAB9ACRHBP | |
| SCHEMBL20197221 | 0.73 | SREBF2 (0.55) | KDM4ELMNAMAPTALDH1A1 | |
| SCHEMBL20197336 | 0.72 | CYP19A1 (0.46) | KDM4ESMN1; SMN2NPC1RAB9ACRHBP | |
| SCHEMBL20197228 | 0.72 | CYP1A1 (0.42) | KDM4ESMN1; SMN2NPC1RAB9ACRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3038622-B1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | MEDIVATION TECH LLC (US) | 2018-05-30 | — | — | EP | disclosed |