Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4E | P06730 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.46 |
| ▸ | TACR3 | P29371 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16535280 | 0.85 | EIF4E (0.52) | EIF4EKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20197309 | 0.80 | CYP1B1 (0.41) | EIF4EKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20197302 | 0.79 | SMN1; SMN2 (0.46) | EIF4EKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20197232 | 0.76 | EIF4E (0.43) | EIF4EKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20197276 | 0.74 | EIF4E (0.45) | EIF4EKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20197341 | 0.74 | CYP1B1 (0.35) | EIF4EKDM4ESMN1; SMN2ALDH1A1SCN9A | |
| SCHEMBL20197240 | 0.73 | ALDH1A1 (0.53) | EIF4EKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20197306 | 0.73 | PRKD1 (0.39) | KDM4EALDH1A1 | |
| SCHEMBL19887244 | 0.73 | EIF4E (0.53) | EIF4EKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20197228 | 0.72 | CYP1A1 (0.42) | EIF4EKDM4ENPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3038622-B1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | MEDIVATION TECH LLC (US) | 2018-05-30 | — | — | EP | disclosed |