Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.33 |
| ▸ | KDM6B | O15054 | 1/20 | 0.32 |
| ▸ | KDM5C | P41229 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20000719 | 0.98 | KDM4A (0.38) | KDM4AKDM4CALDH1A1LMNAEPHX2 | |
| SCHEMBL18643021 | 0.83 | DNM1 (0.45) | ALDH1A1LMNATSHR | |
| SCHEMBL23196453 | 0.83 | DNM1 (0.45) | ALDH1A1LMNATSHR | |
| SCHEMBL18857631 | 0.82 | ALDH1A1 (0.48) | ALDH1A1LMNACYP3A4ALOX15TSHR | |
| SCHEMBL24556946 | 0.81 | TSHR (0.33) | LMNAKDM6BKDM5CEGLN1PHF8 | |
| SCHEMBL25587548 | 0.81 | PHF8 (0.42) | KDM6BKDM5CEGLN1PHF8KDM2A | |
| SCHEMBL22640952 | 0.79 | ALDH1A1 (0.51) | ALDH1A1LMNAKDM6BKDM5CEGLN1 | |
| SCHEMBL24158129 | 0.78 | SLC6A5 (0.48) | KDM4ALMNAEPHX2PAOXTSHR | |
| SCHEMBL25672058 | 0.78 | KDM6B (0.33) | LMNAKDM6BKDM5CEGLN1PHF8 | |
| SCHEMBL22640979 | 0.77 | ALDH1A1 (0.45) | ALDH1A1LMNAKDM6BKDM5CEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2917195-B9 | SPLICEOSTATIN ANALOGS | PFIZER (US) | 2018-05-30 | — | — | EP | disclosed |