Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | KLK1 | P06870 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.34 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.34 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17835085 | 0.86 | HRH3 (0.49) | ALDH1A1HRH4HRH3JAK3JAK2 | |
| SCHEMBL17833993 | 0.81 | HRH3 (0.51) | ALDH1A1HRH3KCNH2 | |
| SCHEMBL20781647 | 0.77 | HRH3 (0.39) | ALDH1A1HRH3 | |
| SCHEMBL24296223 | 0.73 | ALDH1A1 (0.39) | ALDH1A1HRH3KCNH2PDE10A | |
| SCHEMBL31200401 | 0.73 | GSK3B (0.41) | ALDH1A1JAK3JAK2SMN1; SMN2PKM | |
| SCHEMBL16600416 | 0.72 | CHEK1 (0.47) | HRH4HRH3JAK3JAK2JAK1 | |
| SCHEMBL31200411 | 0.70 | WNT1 (0.45) | ALDH1A1JAK3JAK2SMN1; SMN2KLKB1 | |
| SCHEMBL13884225 | 0.69 | CCR3 (0.65) | ALDH1A1CCR3PRMT6CARM1PRMT3 | |
| SCHEMBL22340469 | 0.68 | SMN1; SMN2 (0.54) | ALDH1A1SMN1; SMN2PKMCCR3PRMT6 | |
| SCHEMBL23014031 | 0.68 | DRD2 (0.44) | ALDH1A1PKMCCR3KLKB1KLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3033336-B1 | INHIBITORS OF PLASMA KALLIKREIN | KALVISTA PHARMACEUTICALS LTD (GB) | 2018-05-30 | — | — | EP | disclosed |