Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHCY | P23526 | 9/20 | 0.33 |
| ▸ | IKBKB | O14920 | 5/20 | 0.32 |
| ▸ | CHUK | O15111 | 4/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.32 |
| ▸ | GDA | Q9Y2T3 | 2/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.31 |
| ▸ | MC3R | P41968 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.31 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15186166 | 0.79 | AHCY (0.51) | AHCYIKBKBADORA2AADORA1ADORA2B | |
| SCHEMBL21338966 | 0.77 | AHCY (0.31) | AHCYIKBKBCHUK | |
| SCHEMBL20200120 | 0.73 | APLNR (0.36) | AHCY | |
| SCHEMBL27285050 | 0.71 | ADORA2A (0.35) | IKBKBCHUKADORA2AADORA1GDA | |
| SCHEMBL25472935 | 0.71 | ADORA1 (0.44) | ADORA2AADORA1 | |
| SCHEMBL30206029 | 0.69 | IKBKB (0.33) | IKBKBCHUKADORA2AADORA1GDA | |
| SCHEMBL12256556 | 0.69 | IKBKB (0.37) | IKBKBCHUKADORA2AADORA1POLB | |
| SCHEMBL26536287 | 0.68 | F2RL1 (0.37) | — | |
| SCHEMBL27404282 | 0.64 | GDA (0.35) | ADORA2AADORA1GDAPIK3CDPOLB | |
| SCHEMBL9601945 | 0.64 | CASP3 (0.43) | IKBKBCHUKPIK3CDDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541792-B1 | TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2020-12-23 | — | — | EP | disclosed |
| WO-2018097944-A1 | TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2018-05-31 | — | — | WO | disclosed |