Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | S100B | P04271 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LATS1 | O95835 | 1/20 | 0.37 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
| ▸ | TERT | O14746 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25685748 | 0.84 | AKR1B1 (0.42) | AKR1B1ALDH1A1LMNAHTTALDH1A3 | |
| SCHEMBL18509336 | 0.83 | CYP3A4 (0.38) | AKR1B1S100BALDH1A1MAPTLMNA | |
| SCHEMBL20201658 | 0.82 | AKR1B1 (0.46) | AKR1B1MAPTSMN1; SMN2RAB9AHTT | |
| SCHEMBL10348155 | 0.78 | ALDH1A1 (0.42) | S100BALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL17269560 | 0.76 | AKR1B1 (0.47) | AKR1B1ALDH1A1SMN1; SMN2HTTNISCH | |
| SCHEMBL1341419 | 0.75 | S100B (0.50) | S100BALDH1A1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL27865235 | 0.75 | ALDH1A3 (0.44) | S100BALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL10604958 | 0.75 | HCRTR1 (0.38) | S100BALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL20207784 | 0.75 | AKR1B1 (0.44) | AKR1B1ALDH1A1LMNAHTTNISCH | |
| SCHEMBL13736411 | 0.75 | LOXL2 (0.39) | S100BLMNALATS1LATS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018128720-A1 | URACIL CONTAINING COMPOUNDS | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-07-12 | — | — | WO | disclosed |
| WO-2018098207-A1 | HYDANTOIN CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |
| WO-2018098206-A1 | HYDANTOIN CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |