Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20376455 | 0.89 | HTR2A (0.38) | PDE10AHTR2AHTR2CHTR2BRIPK1 | |
| SCHEMBL20201733 | 0.85 | SCN9A (0.46) | SCN9A | |
| SCHEMBL21325507 | 0.82 | HTR2C (0.40) | PDE10AHTR2AHTR2CHTR2BRIPK1 | |
| SCHEMBL21325098 | 0.82 | DHFR (0.41) | PDE10AHTR2AHTR2CHTR2BRIPK1 | |
| SCHEMBL24777832 | 0.81 | SCN9A (0.49) | SCN9A | |
| SCHEMBL9896972 | 0.81 | SCN9A (0.36) | PDE10AHTR2AHTR2CHTR2BRIPK1 | |
| SCHEMBL13475569 | 0.79 | HPGD (0.49) | ELANEHPGD | |
| SCHEMBL18374001 | 0.79 | HTR2C (0.51) | PDE10AHTR2AHTR2CHTR2BRIPK1 | |
| SCHEMBL16135136 | 0.79 | CYP3A4 (0.40) | PDE10AHTR2AHTR2CHTR2BRIPK1 | |
| SCHEMBL20201700 | 0.79 | ALDH1A1 (0.42) | HTR2CHTR2BRIPK1RETCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018128720-A1 | URACIL CONTAINING COMPOUNDS | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-07-12 | — | — | WO | disclosed |
| WO-2018098206-A1 | HYDANTOIN CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |
| WO-2018098208-A1 | NITROGEN RING LINKED DEOXYURIDINE TRIPHOSPHATASE INHIBITORS | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |