Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4526795 | 0.89 | MYC (0.39) | MYCRECQLPARP14XDHABCG2 | |
| SCHEMBL454924 | 0.85 | RECQL (0.52) | MYCRECQLPARP14XDHABCG2 | |
| SCHEMBL4833060 | 0.81 | MYC (0.37) | MYCRECQLPARP14XDHABCG2 | |
| SCHEMBL14614499 | 0.81 | LOXL2 (0.45) | MYCKDM4EALDH1A1GAAMAPT | |
| SCHEMBL2960938 | 0.81 | MEN1 (0.52) | MYCPARP14XDHABCG2PRMT5 | |
| SCHEMBL2547947 | 0.81 | CTSK (0.40) | MYCKDM4EALDH1A1GAAHPGD | |
| SCHEMBL27677466 | 0.81 | MYC (0.37) | MYCPARP14XDHABCG2PRMT5 | |
| SCHEMBL28024986 | 0.81 | MYC (0.37) | MYCPARP14XDHABCG2PRMT5 | |
| SCHEMBL741908 | 0.80 | PRMT5 (0.38) | MYCRECQLPARP14XDHABCG2 | |
| Hydrochloric Acid SCHEMBL2020607 | 0.80 | LOXL2 (0.44) | MYCKDM4EALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7956060-B2 | Pyrimidine derivative compound | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2011-06-07 | — | — | US | disclosed |
| CN-101516835-A | Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof | OSURF OHIO STATE UNIVERSITY RE (US) | 2009-08-26 | — | — | CN | disclosed |
| US-20090156614-A1 | Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof | OHIO STATE UNIVERSITY RESEARCH FOUNDATION | 2009-06-18 | — | — | US | disclosed |
| US-20090156614-A1 | Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof | OHIO STATE UNIVERSITY RESEARCH FOUNDATION | 2009-06-18 | — | — | US | disclosed |
| EP-2041077-A2 | SELECTIVE ANDROGEN RECEPTOR MODULATORS, ANALOGS AND DERIVATIVES THEREOF AND USES THEREOF | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2009-04-01 | — | — | EP | disclosed |
| US-20090012060-A1 | Antitumor Agent | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-01-08 | — | — | US | disclosed |
| US-7351822-B2 | Serine protease inhibitors | ELI LILLY AND COMPANY (US) | 2008-04-01 | — | — | US | disclosed |
| WO-2008011072-A2 | SELECTIVE ANDROGEN RECEPTOR MODULATORS, ANALOGS AND DERIVATIVES THEREOF AND USES THEREOF | OSURF (OHIO STATE UNIVERSITY RESEARCH FOUNDATION) (US) | 2008-01-24 | — | — | WO | disclosed |
| EP-1749827-A1 | ANTI-TUMOR AGENT | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-02-07 | — | — | EP | disclosed |
| US-6946467-B2 | Serine protease inhibitors | ELI LILLY AND COMPANY (US) | 2005-09-20 | — | — | US | disclosed |
| EP-1289972-B1 | SERINE PROTEASE INHIBITORS | LILLY CO ELI (US) | 2004-09-08 | — | — | EP | disclosed |
| US-20040142963-A1 | Serine protease inhibitors | LIEBESCHUETZ JOHN WALTER (GB) | 2004-07-22 | — | — | US | disclosed |
| US-20030055246-A1 | Serine protease inhibitors | PROTHERICS MOLECULAR DESIGN LIMITED (GB) | 2003-03-20 | — | — | US | disclosed |
| EP-1289972-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001096323-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |
| US-5217963-A | Antiischemic, antiepileptic agent | CIBA-GEIGY CORPORATION (US) | 1993-06-08 | — | — | US | disclosed |
| US-5057506-A | Anticonvulsants, antispasmodic and antischemic agents | CIBA-GEIGY CORPORATION (US) | 1991-10-15 | — | — | US | disclosed |
| US-4906621-A | Certain 2-carboxypiperidyl-alkylene phosphonic acids and esters thereof useful for the treatment of disorders responsive to N-methyl-D-aspartate receptor blockade | CIBA-GEIGY CORPORATION (US) | 1990-03-06 | — | — | US | disclosed |
| US-4898854-A | NERVOUS SYSTEM DISORDERS | CIBA-GEIGY CORPORATION (US) | 1990-02-06 | — | — | US | disclosed |
| EP-0275820-A2 | Unsaturated phosphonic acids and derivatives | CIBA-GEIGY AG (CH) | 1988-07-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030055246-A1 | Serine protease inhibitors | CTRL, CPN1, LOXL1 | MYC 4564/4885KDM4E 3205/4885ALDH1A1 2408/4885 |
| US-20090012060-A1 | Antitumor Agent | NR1H3, NR1I3, NR0B1 | MYC 737/4885KDM4E 985/4885ALDH1A1 1834/4885 |
| US-20040142963-A1 | Serine protease inhibitors | SERPINE1, PRSS1, SERPINB1 | MYC 4758/4885KDM4E 3503/4885ALDH1A1 2261/4885 |
| US-20090156614-A1 | Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof | AR, ESRRA, ESRRB | MYC 935/4885KDM4E 1806/4885ALDH1A1 2288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.