SCHEMBL20202016

SCHEMBL20202016

NCCOCCOCCOCCNCc1c[nH]c2nc(N)[nH]c(=O)c12

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PNP P00491 1/20 0.41
TYMS P04818 6/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24701146 0.89 PNP (0.42) PNPTYMS
SCHEMBL19929241 0.88 PNP (0.48) PNPTYMS
SCHEMBL24700868 0.86 PNP (0.47) PNPTYMS
SCHEMBL20202021 0.84 PNP (0.36) PNP
SCHEMBL20206650 0.84 PNP (0.36) PNP
SCHEMBL20202019 0.82 PNP (0.41) PNPTYMS
SCHEMBL21324597 0.82 PNP (0.41) PNPTYMS
SCHEMBL19929245 0.80 PNP (0.48) PNPTYMS
SCHEMBL24231643 0.80 TYMS (0.46) TYMS
SCHEMBL21325130 0.79 PNP (0.39) PNPTYMS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220281860-A1 COMPOUNDS AND METHODS OF TREATING RNA-MEDIATED DISEASES ARRAKIS THERAPEUTICS, INC. 2022-09-08 US disclosed
US-20180148764-A1 ENZYMATIC MODIFICATION OF NUCLEIC ACIDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2018-05-31 US disclosed
US-20180148764-A1 ENZYMATIC MODIFICATION OF NUCLEIC ACIDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2018-05-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220281860-A1 COMPOUNDS AND METHODS OF TREATING RNA-MEDIATED DISEASES NSUN3, NSUN2, POLRMT PNP 578/4885TYMS 1058/4885
US-20180148764-A1 ENZYMATIC MODIFICATION OF NUCLEIC ACIDS RNGTT, UNG, RNASEL PNP 41/4885TYMS 172/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.